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Under oxidative stress, NRF2 translocates into the nucleus and forms a heterodimer with small musculoaponeurotic fibrosarcoma proteins and binds to the antioxidant response element consensus sequence for transcriptional regulation (196) ( Figure 3 )

Injection of PPI (3 mg/kg, dissolved in 1% DMSO +5% PEG300 + 5% Tween 80 + 89% deionized water), as described previously [26], or the control solution with the same solvent

Furthermore, ascites represses the ferroptosis-induced membrane upregulation of the transferrin receptor (TFRC) and labile iron

also found senescence in human non-senescent cells and exaggeration of the senescence-associated secretory phenotype (SASP)-related inflammatory molecules in human senescent cells with the application of the SARS-CoV-2 spike protein [111]