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Findings from EU-IGFD registry data suggest that treatment initiation for treatment-nave pre-pubertal patients occurs at a mean (SD) age of 6.07 (3.49) years for individuals with Laron syndrome and 8.44 (3.45) years for those with uncharacterized forms of IGFD [44]

In addition, defects are observed regarding the functionality of regulatory T cells and B cells in MG patients

For instance, among children aged 6 months to 5 years, ID rates range from 10.6% in Colombia to 26.1% in Liberia, with intermediate values observed in Cameroon (20.2%), Laos (18.4%), and Mexico (14.8%)