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The second mechanism by which glutathione causes lightening of skin is inhibition of transfer of tyrosinase to premelanosomes for melanin synthesis.[] The third mechanism of tyrosinase inhibition is through its antioxidant effect as it scavenges the free radicals generated in the epidermis following UV light irradiation

Amien AI, Fahmy SR, Abd-Elgleel FM, Elaskalany SM (2015) Renoprotective effect of Mangifera indica polysaccharides and silymarin against cyclophosphamide toxicity in rats

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Differences in liver metabolism, immune modulation, and hormone signaling between male and female hosts could contribute to variation in disease progression and treatment responses