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This target is based on the observation that adverse outcomes were associated with ESA use with hemoglobin targets higher than 13 g/dL ( Table 1 )

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The S-targeting mAbs included both neutralizing and non-neutralizing molecules which displayed high, yet differential, activity in multiple antibody effector assays dependent on the antigenic target, suggesting a role for the Fv in facilitating both neutralization and Fc effector functions as all isolated mAbs were cloned into the same rh-IgG1 backbone

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