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For instance, exosomal miR-140-5p suppresses SLC7A11 expression, impairing the system xc-/GSH/GPX4 axis, reducing GSH synthesis, and promoting cardiomyocyte ferroptosis and cardiac injury [101]

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As stated most clearly by (Vasudevan and Pfaff, 2007), The novel idea that genomic transcription by hormones, i.e, ligand-dependent transcription at hormone response elements, can be affected by membrane-initiated signal transduction events initiated by cognate or noncognate ligands is a paradigm shift in nuclear receptor biology