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To make sure the direction of effect we got is sensible we notice that with an overabundance of the oxidized form the tendency to be oxidized by oxygen is somewhat lower as seen by the fact that the redox potential is now closer than before to that of the oxygen/water electron exchanging pair (+0.82V)

GSSG was docked to the proximity of all five cysteine residues, with each binding site defined as the center of the cysteine ( i ) and adjacent residues ( i 1 )

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1,2 Importantly, cellular senescence represents a stress response that induces irreversible cell cycle arrest, serving as a hallmark of aging