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Furthermore, for specific compounds, additional key mechanisms such as Fas-mediated signal transduction, loss of cellular redox homeostasis, ATP depletion, changes in ion channels, and activation of kinases and caspases, among others, have been highlighted

Yes, tolerance is often reversible or manageable without discontinuing therapy

IBD primarily encompasses ulcerative colitis (UC) and Crohns disease (CD) ( Similar to CD, mouse models of experimental colitis trigger a Th1 type immune response, reflected by the infiltration of IFN-producing T cells in the colon ( via intrarectal instillation of the chemicals

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