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Arrhythmia complications are usually observed when the QT interval is greater than 500 ms or changes more than 60 ms, and in this situation, according to recommendations from the Food and Drug Administration 30 and the European Medicines Agency 31 , treatment should be discontinued or given at a lower dose

Notably, a study involving approximately 276,000 participants from the UK Biobank cohort revealed that permanent night shift work, a condition acknowledged to reduce 24-hour melatonin levels [41], was associated with a 1.5-fold higher risk of developing AD during a median follow-up of 9 years [42]

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