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[58] [59] [60] [61] On 23 August 2021, the PfizerBioNTech vaccine became the first COVID-19 vaccine to be approved in the US by the Food and Drug Administration (FDA)

112 PEGylation can be performed at various sites, including the N-terminus, C-terminus, amino groups, sulfhydryl groups, and via bridging strategies

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In vitro , in comparison with control, healthy animals, the assessment of splenic cells (day 21) demonstrated that the 6-methylprednisolone animals had declined reactivity to nitrogen, while the addition of BPC 157 (1 g/g cream) returned cell reactivity to normal values (Mikus et al., 2001