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a G protein-coupled receptor that mediates vision in dim light by controlling activity of transducin, a G protein an enzyme that catalyzes the conversion of ATP into cytoplasmic 3',5'-cyclic adenosine monophosphate (cAMP) an ion channel that allows transmembrane passage of calcium ions in a manner that is regulated the membrane voltage gradient proteins that bind G protein-coupled receptors to inhibit signaling through G protein activation and ultimately, to permanently terminate signaling by promoting endocytotic internalization and degradation of the receptor

Subsequent laboratory studies have explored its observed effects on senescent chondrocytes, endothelial cell senescence via p53 signaling, and senescent cancer-cell models

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This finding should not be interpreted as a new result but as convergent evidence, corroborating the primary item-level analyses