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To uncover the underlying mechanisms, the researchers analyzed hippocampal tissue focusing on dentate gyrus, where they quantified neural progenitor proliferation and neurogenesis through BrdU, immunofluorescence for Sox2, GFAP, DCX and NeuN, and unbiased stereological cell counting

Long-term effect of acetyl-L-carnitine for antiretroviral toxic neuropathy

Acknowledgments The authors gratefully acknowledge the contributions of researchers in the field of MASLD and carnitine metabolism, whose foundational work has informed this study

Metabolomic analysis revealed that VPA -induced abnormal liver function resulted in the accumulation of serum long-chain acylcarnitines (LCACs), and the reduced expression of -FAO relevant genes (Carnitine palmitoyltrans-ferase (CPT)1, CPT2 and Long-chain acyl-CoA dehydrogenase (LCAD)), indicating the disruption of -FAO