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Statements Author contributions XB: Writing review and editing, Formal Analysis, Supervision, Methodology, Writing original draft, Project administration, Software, Data curation, Investigation, Conceptualization, Visualization, Resources, Funding acquisition, Validation

Zinc also regulates the endolysosomal tethering machinery through the HOPS complex, whose VPS18 and VPS41 subunits contain zinc-binding RING domains essential for heterodimer formation and complex stability, which is critical for autophagosomelysosome and endosomelysosome fusion 104

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Studies observed that IL-1 and IL-1 were related to the NF-kB signaling activation and liver damage, playing a central role inALF pathogenesis (98)