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This is due not only to the structural similarity between insulin and the IGFs, but also to the high degree of homology between the insulin receptor (IR) and the IGF receptors (Figure 1)

Therefore, the aim of this review is to discuss the role of MAPK pathway in cisplatin based chemotherapy and to elucidate the possibilities of combination of RSK inhibition along with cisplatin in order to increase the anticancer effect and reduce resistance and toxic side effects of cisplatin

Allowing adequate time (30-60 seconds) for alcohol to dry before proceeding with injection to prevent alcohol introduction into tissue

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