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PMCID: PMC2878077

Through secure telehealth appointments, users can explore treatment options, including compounded prescriptions from licensed pharmacies, when medically appropriate

FIGURE 1 4 Traditional Chinese medicine (TCM) compounds treat AD through the MAPK signaling pathway A substantial body of research has demonstrated that plant-derived natural compoundssuch as flavonoids, alkaloids, saponins, and phenolic acidsmodulate neurotransmitter levels through multiple signaling pathways and cascade reactions, thereby improving behavioral performance and memory function, reducing A protein deposition, inhibiting acetylcholinesterase (AChE) activity, preventing neuronal apoptosis, and enhancing cerebral antioxidant capacity

Specifically, we show that AR directly represses BCL-2 transcription via binding to multiple ARBS across the BCL-2 genomic region, especially the ARBS1 around the promoter, and castration and ARPI treatment block AR engagement to most ARBS leading to de-repression of BCL-2 transcription