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While inhalation therapy has many benefits, it also has some drawbacks

Those activities result in neuronal hyperpolarization and suppressed release of neurotransmitters, including substance P and glutamate, thus attenuating nociceptive signal transmission [55,56,57,58]

Here, we provide the first evidence of improved healthspan and age-related survival with a therapeutic mAb by demonstrating that treatment with an IGF-1R antagonist in older mice significantly and preferentially improves several indices of healthspan, reduced death from neoplastic disease, and increased mean and median lifespan in females

Neuro Oncol (2023) 25(11):192031