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The peptide crosses the blood-brain barrier to some extent, which is important for a compound intended to affect central nervous system function

The role of microglia in the pathobiology of neuropathic pain development: what do we know

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Furthermore, S1P has been shown to alleviate genotoxic stress-induced sperm DNA damage and to enhance the expression of a crucial DNA repair gene, BRCA1 [61].In the cNHEJ pathway, it is mainly formed by Ku70 and Ku80 to form a heterodimer, which attracts the recombinase Artemis, and then convenes DNA-dependent protein kinase catalytic subunit (DNA-PKcs), X-ray repair cross-complementing protein 4 (XRCC4), DNA ligase 4 (LIG4), and XLF to form a complex, which ultimately completes the repair process, in phases G1 and G2 [62]