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Additionally, the most commonly used in vivo models of IPF, chemically induce fibrosis with Bleomycin or Fluorescein isothiocyanate (FITC) which fail to recapitulate the chronic and progressive nature of human IPF 3

Plant-based nutritional strategiesincluding selenium, iodine, Mediterranean dietary patterns, and selected phytochemicalsoffer biologically plausible and generally safe adjunctive approaches by targeting oxidative stress, neuroinflammation, and neurotransmitter dysregulation

(3) It may influence growth hormone synthesis without interacting with other pituitary hormones

It is characterized by cold-sensitive peripheral paresthesia (hands and feet dysesthesia and paresthesia) and motor symptoms (e.g., prolonged muscular contractions, tetanic spasms, and fasciculations) [12] (Fig