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Water soluble or hydrophilic antioxidants are active in the blood plasma while the water insoluble antioxidants protect the cell membranes

Furthermore, the mitochondria often exhibit a loss of cristae and may show ruptures in their outer membranes (20,27,28)

Manganese porphyrins and their Schiff base complexes are characterized with high metal-ligand stability, the accessibility of their metal centers toward multiple oxidation states, and their reactivity toward different types of ROS, which have provoked extensive in vivo studies 6

Furthermore, studies have suggested that the therapeutic synergy between sitagliptin and metformin co-administration can increase mRNA and protein expression levels (Daneshjou et al., 2022)