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iv) Interestingly, several reports have recently documented the pivotal role of the autophagy process in modulating inflammation and ER stress

The absence of specialized literature refers to the lack of biochemical and signaling knowledge mechanisms regarding the immunomodulatory effects in mammals, except for a few species used in laboratory studies

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Longer circulation times are preferable for brain delivery strategies, with neutral and zwitterionic NPs showing slower clearance from the bloodstream compared with negatively and positively charged NPs, which instead presented shorter half-lives ( Altogether, polymer-based NPs represent a promising and competitive alternative to other conventional carbon-based and bio-based nanostructures eligible for potential clinical applications, such as fullerene, carbon dots (CDs) and nanotubes as well as liposomes (Bilal et al., 2020