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In three other xenogeneic models of A549 cell origin, treatment with metformin significantly reduced tumor growth and metastatic capacity in vivo, and reduced the expression of proteins such as Ki-67, proliferating cell nuclear antigen (PCNA), Akt and Myc (72,78,81)

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Vitamin B12 (as Methylcobalamin & Hydroxycobalamin) This vitamin is required for red blood cell formation, DNA synthesis, and proper neurological function and repair due to its critical role in myelin sheath health and regeneration