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Presenilin hypothesis in AD The calcium hypothesis of AD implies that genetic abnormalities producing flavin adenine dinucleotide (FAD) also lead to dysregulation of neuronal calcium (Ca2 +) processing and may contribute to AD pathogenesis

Oxidative stress-induced chemokine production mediates CD8(+) T cell skin trafficking in vitiligo

Contrary to prior conclusions from preclinical models and retrospective studies suggesting that NAFLD-related HCC might resist immune checkpoint inhibitors (ICIs), this patient-level analysis found no significant differences in overall response rate (ORR), progression-free survival (PFS), or overall survival (OS) across liver disease etiologies, challenging earlier assumptions about NAFLDs impact on ICI outcomes (2225)