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Quality control for the neurodevelopmental tools All methods that will be used to measure neurodevelopment have been translated, adjusted and/or piloted in previous studies at the current study site

Biomacromolecules 14 , 43684376 (2013)

Pharmacokinetic Profile Route of Administration Subcutaneous Dosing Frequency Once daily Route of Administration : Subcutaneous injection Dosing Frequency : Once daily Half-Life : ~38 minutes in HIV+ patients 2 Formulation : Lyophilized acetate salt for reconstitution Formulation & Handling Reconstitute lyophilized powder in sterile bacteriostatic water for injection (0.9% benzyl alcohol) Store reconstituted solution at 28C and use within 14 days Unreconstituted vials should be stored at 20C in a dry, light-protected environment Avoid repeated freeze-thaw cycles

The process involves inserting a needle through the vial's rubber stopper and slowly adding bacteriostatic water to the lyophilized peptide