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Genome and biochemical analyses of pathogenic and commensal species revealed that all Neisseria species have a highly conserved nitric oxide reductase (NorB) and nitrite reductase (AniA or NirK), while only Neisseria mucosa contained a nitrate reductase (Nar), and only Neisseria lactamica , Neisseria cinerea , Neisseria subflava , Neisseria flavescens , and Neisseria sicca contained a nitrous oxide reductase (Nos) complex ( Neisseria species is the lack of a functional Nos system in the pathogenic species N

Nevertheless, it is not an impervious barrier, but rather selectively regulates what passes through the paracellular space

For patients with symptoms such as brain fog, anxiety, fatigue, histamine intolerance, or chemical sensitivity, these toxicants may be the missing link in an otherwise thorough functional assessment