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For one or two months out of every three they are too exhausted to function

Complementing these findings, (Pan et al

These trials did not show clear advantages over placebo on standard PD scales, partly because sample sizes were small and placebo groups improved

Silibinin improves tumor immunity Silibinin inhibits tumor growth through immunomodulatory activities, such as regulating immune cells (Tregs, macrophages, DCs, NK cell), inhibiting inflammatory cytokines (IFN- , IL-2, IL-6, IL-10, IL-12, TNF- , and TGF- ), and modulating immune check points (PD-L1 and PD-1) [889,890,891,892,893]