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In vitro cytotoxicity assays using SH-SY5Y (human neuroblastoma), Caco-2 (intestinal permeability), and hCMEC/D3 (human brain endothelial) cells demonstrated that nanoencapsulation significantly reduced the inherent cytotoxicity of free coumarin

Sulofenur [( N -(5-indanesulfonyl)- N -(4-chlorophenyl)urea, LY18664], the prototypic member of this class ( Figure 2C ), was evaluated in clinical trials on a variety of patients with kidney (Mahjoubi et al., 1993), ovary (OBrien et al., 1992), breast (Talbot et al., 1993), lung (Munshi et al., 1993), and stomach (Kamthan et al., 1992) cancers

The in vitro evidence showed the positive effect of crude HEM and its compounds in promoting OL maturation, which substantiates the potential use of HEM and its small active compounds for the treatment of neurodegeneration-associated demyelination

Microglial activity in people at ultra high risk of psychosis and in schizophrenia: an [ 11 C]PBR28 PET brain imaging study