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10.1007/s11596-018-1989-8 214 YuS.LiuF.WangC.ZhangJ.ZhuA.ZouL.et al (2018)

AOD-9604 might be 300mcg once daily

These findings suggest that AtGLRs coordinate phytohormone signalling and Ca 2+ homeostasis to fine-tune cold adaptation responses

Specifically, the malate/aspartate shuttle proteins MDH2, -KG/malate carrier, and GOT2 were found to be hyperacetylated leading to suppression of the transport and oxidation of cytosolic NADH in mitochondria, which correlated with decreases in oxygen consumption and cardiac energetics (manifested by a reduction in phosphocreatine/ATP) (42, 47)