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For men, it may result in lower sperm count and motility

Again, not because its been shown to be harmful, but because nobody has shown its safe, and we dont know combined with runs indefinitely is not a foundation to build a protocol on

Symptoms include seizures, arrhythmias, low blood pressure, severe muscle contraction (tetany), and death.[230] In a recent review of 10 cases, the elderly patients had been taking PPIs for an average of 8.3 yrs.[226] They suffered from severe symptoms of low magnesium and there was significant morbidity related to fatigue, unsteadiness, severe muscle contraction, seizures, cardiac arrhythmias, and multiple hospitalizations

PMID 11935176