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The long chain fatty acids first bind to CoA to form the fatty acyl CoA that in turn binds with l-carnitine, and the resulting acylcarnitine is shuttled through the inner membrane and into the mitochondria (Figure 2)

doi: 10.1136/gut.2005.083634 20 KadiriJJThapaKKaipioKCaiMHrubyVJRinneP

Additionally, this approach is scalable to generate mini-liver organoids that contain vasculature while recapitulating the complexity of cell types associated with the liver