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Insulin plays a key role in regulating lipoprotein synthesis, and insulin resistance (IR) in DM causes the liver to overproduce lipoproteins, resulting in hyperlipidemia (222)

It explains why anti-inflammatory treatments like topical steroids provide relief, and why newer treatments targeting specific immune pathways show promise

Microecological preparations, including probiotics, prebiotics and symbiotics, aim to mitigate oxidative stress and inflammation, reduce the reversion of dysbiotic microbiota, effectively alter producers of SCFAs, and attenuate renal fibrosis [148]

It is often believed that the best place to find effective and safe depigmentation ingredients is in natural products