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Testing hypotheses of OSC thiol reactivity and virulence modulation - Engineered strains with altered thiol-redox capacity (e.g., glutathione-deficient mutants, Nrf2 or Keap1 variants) provide controlled systems to dissect the mechanistic contribution of sulfur electrophilicity, S-thiolation, and redox stress responses to OSC-mediated antimicrobial or immunomodulatory activity (Yamamoto et al., 2018)

Additionally, since they found that selenium is positively associated with glutathione peroxidase, it may suggest a possible mechanism of the involvement of this trace metal in the pathogenesis of diseases, i.e., by impairing the sphere of oxidative stress [91]