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doi: 10.3390/ijms23147965 42 KohWKwakHCheongELeeCJ

These involve vascular quiescence, vascular tone and structure regulation, angiogenesis, the control of hemostasis and inflammation, endocrinemetabolic functions, and protection from tissue and ischemic injuries (12)

Also, CML levels correlated with severity of disease [99]

Within mitochondria the enzyme glutaminase (GLS) acts on glutamine to produce -ketoglutarate (-KG), and -KG subsequently enters the TCA cycle to support energy production and anaplerosis