glutathione depletion paracetamol Illustration of the effects of acetaminophen on glutathione, Too much paracetamol = dangerous
Too much paracetamol = dangerous because of how your liver processes it. *Normal dose:* About 90 95% gets broken down safely by glucuronidation + sulfation non toxic stuff you pee out. *The problem The gamma glutamyl pathway after glutathione depletion due to Download Scientific Diagram Ferroptosis and Intrinsic Drug induced Liver Injury by Acetaminophen and Other Drugs: A Critical Evaluation and Historical Perspective Paracetamol toxicity Biochemical Basis Lecture
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