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It furthermore achieves good effects against the aging processes

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The target DNA in the genome may be manipulated by deletions, insertions, and/or mutations such as retroviral insertions, artificial chromosomal techniques, gene insertions, random insertions using tissue-specific promoters, gene targeting, transposable elements, and/or any other method for introducing foreign DNA or producing modified DNA/modified nuclear DNA

As such, the choice of behavioral tests poses challenges for advancing our understanding of the circuit mechanisms underlying AD (Geda et al., 2013