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5 In the 1990s, the inadequate assessment and treatment of pain was recognized as a health emergency and eventually labeled as the 5th vital sign. In the effort to improve pain control and in the wake of new pharmaceutical formulations, liberal opioid prescribing eventually led to a national opioid crisis

Unlike many existing drugs that primarily target appetite suppression, Tesofensine is believed to influence multiple pathways within the brain, potentially impacting both appetite and energy expenditure

However, the techniques used to do so are newer, leading to shorter treatment times and faster recovery