superoxide dismutase and glutathione peroxidase Figure 2 — Are epidermal stem cells unique with respect to aging? SOD, superoxide dismutase; GPX, glutathione

Sp1 contains zinc finger domains and is involved in the regulation of a wide range of genes related to cell growth, differentiation, and metabolism

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If these levels remain chronically low, it can contribute to the development or worsening of various disease states, including: (3, 4) Premature aging (and aging in general) Neurodegenerative disorders Cancer Cognitive impairment Diabetes HIV/AIDS Autoimmunity Infertility Mental health disorders Hypertension Fatty liver disease That doesnt cover the full spectrum, but it gives you a pretty good idea of how important glutathione is

excess ROS cause inflammatory signalling, whereas chronic inflammation produces more ROS, both of which sustain tissue damage and cannot resolve the inflammatory stage