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doi: 10.1038/sj.bjp.0703392 47

But what may actually be happening is a condition called Estrogen Dominance, where there is an increase in the overall estrogen burden in the body

This represents the most common situation

Targeting CAF-derived IL-6 in combination with immune checkpoint blockade (e.g., anti-PD-L1 therapy) has shown synergistic effects in reducing tumor progression and prolonging survival in preclinical models, underlining the contribution of IL-6-driven MDSC recruitment to immune suppression in PDAC