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He received a diagnosis of B 12 deficiency 10 years ago, and during the covid-19 pandemic he switched from intramuscular hydroxocobalamin 1000 mcg once monthly to oral B 12 supplementation

Baseline reductions in structural connectivity also predict progression to poor cognitive outcomes at 3-year follow-up 141 and in PD patients with MCI they predict progression to dementia within 5 years 144 , with interhemispheric frontal and parietal connections being most implicated in cognitive impairment 141,144,145

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Conclusions Urolithin A and spermidine are two promising compounds that have gained significant attention for their potential to enhance cellular health, promote longevity and mitigate the effects of ageing through the activation of autophagic and mitophagic pathways