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From a mechanistic point of view, a discrete increase of NO was found from an intracellular amastigote model with a concentration dependence, which suggested a specific effect against infected macrophages that could be associated with an immunostimulation response

doi: 10.1146/annurev.med.60.042307.110802 207 MathPGtzVSteteKWalzerDHilgerHPfauSet al

That higher leishmanicidal response against intracellular than axenic forms of the parasite confirms the high preference of the 4-aminoquinoline scaffold toward clinically relevant amastigotes in infected models

As I mentioned, some people may also experience mild digestive discomfort, especially when first starting supplementation