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How Hangovers Work (And Why You Feel So Terrible) When you drink alcohol, your liver breaks it down into acetaldehyde , a toxic compound that causes inflammation, oxidative stress, and those dreaded hangover symptoms

Fluorescence intensity was quantified using the Zeiss ZEN software package

doi: 10.1186/1471-2350-12-25

4.1 Revisiting classical pathways: context-dependent roles of Nrf2 and HDAC inhibition SFN activates the Nrf2 pathway through covalent modification of specific cysteine residues (Cys151, Cys273, and Cys288) on the Keap1 protein, leading to Nrf2 stabilization, nuclear translocation, and transcriptional activation of cytoprotective genes including NAD(P)H quinone oxidoreductase 1 (NQO1), heme oxygenase-1 (HO-1), and glutathione biosynthesis enzymes (63)