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Description

Higher therapeutic doses require a more concentrated formulation or multiple injections per session

Gastrointestinal symptoms may include loss of appetite, weight loss, diarrhoea, or constipation

Moreover, in WT neutrophils, myeloperoxidase (MPO) and elastase were localized along the decondensed web-like DNA filaments, whereas this localization was absent in XKR8-deficient neutrophils, despite comparable MPO expression levels evaluated by immunoblot (Extended Data Fig