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Description

Sequence Confirmation Tandem mass spectrometry or peptide mapping may provide additional evidence concerning residue order

Tube formation assay The extracellular matrix gel-induced tube formation assay was used as an in vitro measurement of angiogenesis

Safety Profile & Reported Adverse Effects The Phase 2b trial (PMID: 23714218) reported a favorable short-term safety profile with no serious adverse events attributed to AOD-9604

Key Takeaways 5-Amino-1MQ inhibits nicotinamide N-methyltransferase (NNMT), increasing cellular NAD+ levels by preserving nicotinamide for NAD+ salvage pathways rather than methylation to N-methyl nicotinamide