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Losing the glutamate at position 3 sharply reduces its binding to IGF-binding proteins, which is why in cell culture it is reported to be roughly ten times more potent than intact IGF-1 at driving cell proliferation and hypertrophy [1]

For example, cytomegalovirus (CMV) infection of the adult cochlea, unlike during the prenatal period, typically causes mild hearing loss and cochlear damage (Juanjuan et al., 2011

Rizzo G, Lagan AS, Rapisarda AM, La Ferrera GM, Buscema M, Rossetti P, Nigro A, Muscia V, Valenti G, Sapia F, Sarpietro G, Zigarelli M, Vitale SG

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