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Quinone moiety Quinone moiety has also been utilized to develop hypoxia-triggered prodrug molecules owing to its ability to undergo electronic rearrangement to cleave covalent bonds under hypoxic conditions 123

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Altogether, zebrafish models can well resemble the growth and the aggressiveness of MB in humans to analyze the effects on MB biology due to the genome editing and the presence of specific mutation and/or activation of oncogenes (130134) ( Figure 1 )

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