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mGluRs modulate cell synaptic transmission via secondary messenger systems and are of three types: group one (mainly post-synaptic, mGluR 1 and mGluR 5 ) and groups two (mGluR 2 and mGluR 3 ) and three (mGluR 4 , mGluR 6 , mGluR 7 , and mGluR 8 ) are largely presynaptic and regulate glutamate release [12]

These findings highlight a significant link between iron metabolism and susceptibility to ferroptosis

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Key membrane proteins participating in astrocytic glutamate release are summarized in Figure 3