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PubMed 4.Prkacin I et al

For instance, inhibition of mitochondrial OXPHOS through agents such as oligomycin or IACS-010759 significantly reduces persister cell viability in multiple cancer models ( 4.3 Intermittent dosing and adaptive treatment strategies Intermittent dosing, or drug holiday strategies, have emerged as innovative approaches specifically designed to exploit the reversible nature of DTP states ( 4.4 Targeting the tumor microenvironment to disrupt persistence The TME substantially influences DTP reversibility by providing paracrine support through growth factors, cytokines, and extracellular matrix remodeling

WGS, whole-genomesequencing

In some cases, a systemic approach may be taken depending on your overall goals