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However, a careful balance is required as excess humidity can overwhelm mucociliary transportation increasing mucosal burden and causing atelectasis from water droplet formation [111]

In the SURPASS-CVOT trial, tirzepatide met its primary endpoint of non-inferiority to dulaglutide for MACE-3, though it lacks an FDA-approved MACE-reduction indication in the U.S.[2] Post hoc cardiorenal analyses examined outcomes beyond the primary MACE endpoint in patients with concurrent cardiovascular and renal risk [3]

It does not occur independently in nature it is produced through solid-phase peptide synthesis in the laboratory