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205 SIRT3 functions as a deacetylase, regulating mitochondrial acetylation levels, which are closely linked to metabolic processes such as OXPHOS, FAO, and the TCA cycle across various organs

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As a small molecule that mimics and potentiates HGF activity while maintaining oral bioavailability and blood-brain barrier penetration, Dihexa offers practical advantages over gene therapy or protein-based approaches for clinical translation

J Mol Neurosci 40(1-2):204210 Miller CL et al (2006) Upregulation of the initiating step of the kynurenine pathway in postmortem anterior cingulate cortex from individuals with schizophrenia and bipolar disorder