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G2019S-LRRK2 mutation enhances MPTP-linked Parkinsonism in mice

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We observed upregulation of DNMTs , but literature also reported increased protein levels and catalytic activity by interaction of DMSO with their enzymes substrates (DNA and AdoMet) 19,29,30

Local injection of an MC4R agonist into the lOT or NAc shell does not affect odor-guided attractive behavior To determine whether the effect of the agonist on odor-guided behavior was specific to its injection into the amOT, mice were implanted with drug cannulas in the bilateral lOT or NAc shell and subjected to behavioral analysis