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The proposed pathway is restoration of pinealocyte function either by direct gene-regulatory effects on serotonin-N-acetyltransferase (AANAT) and related enzymes, or indirectly by reducing neuroendocrine stress signalling

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Preliminary data from trials involving daratumumab with Pembrolizumab (a PD-1 inhibitor), Atezolizumab (another PD-1 inhibitor), and TTI-622 (a CD47 inhibitor) suggest potential synergistic effects, offering new avenues for MM treatment [77]