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Research has found that quercetin, present in Xiao Yao San, targets the lipid metabolism-associated gene PTGS2, inhibits neuronal ferroptosis, and improves the immune response, thereby alleviating BCRD (221)

Epitalon effects on melatonin production and circadian rhythm typically persist for 4 to 6 months after a 10 to 20 day cycle, which is why cycles are repeated only 2 to 3 times per year

However, the observed effects also resulted in significant proliferative action of thyrocytes

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